Dataset Information

Kinetics of microbial translocation markers in patients on efavirenz or lopinavir/r based antiretroviral therapy.

ABSTRACT:

Objectives

We investigated whether there are differences in the effects on microbial translocation (MT) and enterocyte damage by different antiretroviral therapy (ART) regimens after 1.5 years and whether antibiotic use has impact on MT. In a randomized clinical trial (NCT01445223) on first line ART, patients started either lopinavir/r (LPV/r) (n?=?34) or efavirenz (EFV) containing ART (n?=?37). Lipopolysaccharide (LPS), sCD14, anti-flagellin antibodies and intestinal fatty acid binding protein (I-FABP) levels were determined in plasma at baseline (BL) and week 72 (w72).

Results

The levels of LPS and sCD14 were reduced from BL to w72 (157.5 pg/ml vs. 140.0 pg/ml, p?=?0.0003; 3.13 ug/ml vs. 2.85 ug/ml, p?=?0.005, respectively). The levels of anti-flagellin antibodies had decreased at w72 (0.35 vs 0.31 [OD]; p<0.0004), although significantly only in the LPV/r arm. I-FABP levels increased at w72 (2.26 ng/ml vs 3.13 ng/ml; p<0.0001), although significantly in EFV treated patients only. Patients given antibiotics at BL had lower sCD14 levels at w72 as revealed by ANCOVA compared to those who did not receive (??=?-0.47 µg/ml; p?=?0.015).

Conclusions

Markers of MT and enterocyte damage are elevated in untreated HIV-1 infected patients. Long-term ART reduces the levels, except for I-FABP which role as a marker of MT is questionable in ART-experienced patients. Why the enterocyte damage seems to persist remains to be established. Also antibiotic usage may influence the kinetics of the markers of MT.

Trial registration

ClinicalTrials.gov NCT01445223.

SUBMITTER: Vesterbacka J

PROVIDER: S-EPMC3557242 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Kinetics of microbial translocation markers in patients on efavirenz or lopinavir/r based antiretroviral therapy.

Vesterbacka Jan J Nowak Piotr P Barqasho Babilonia B Abdurahman Samir S Nyström Jessica J Nilsson Staffan S Funaoka Hiroyuki H Kanda Tatsuo T Andersson Lars-Magnus LM Gisslèn Magnus M Sönnerborg Anders A

PloS one 20130128 1

<h4>Objectives</h4>We investigated whether there are differences in the effects on microbial translocation (MT) and enterocyte damage by different antiretroviral therapy (ART) regimens after 1.5 years and whether antibiotic use has impact on MT. In a randomized clinical trial (NCT01445223) on first line ART, patients started either lopinavir/r (LPV/r) (n = 34) or efavirenz (EFV) containing ART (n = 37). Lipopolysaccharide (LPS), sCD14, anti-flagellin antibodies and intestinal fatty acid binding ...[more]

PMID: 23383047

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Dataset Information

Kinetics of microbial translocation markers in patients on efavirenz or lopinavir/r based antiretroviral therapy.

Objectives

Results

Conclusions

Trial registration

Publications

Kinetics of microbial translocation markers in patients on efavirenz or lopinavir/r based antiretroviral therapy.

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