Ontology highlight
ABSTRACT:
SUBMITTER: Huang SH
PROVIDER: S-EPMC5701031 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Huang Sung-Hsi SH Lin Shu-Wen SW Chang Sui-Yuan SY Lin Ya-Ting YT Chiang Chieh C Hsiao Chin-Fu CF Sun Hsin-Yun HY Liu Wen-Chun WC Su Yi-Ching YC Hung Chien-Ching CC Chang Shan-Chwen SC
Scientific reports 20171123 1
We investigated the predictors of plasma mid-dose concentrations (C12) of efavirenz by enrolling 456 HIV-positive patients who had received 2 nucleos(t)ide reverse-transcriptase inhibitors plus efavirenz (600 mg daily) for 2 weeks or longer and had their CYP2B6 516G>T polymorphism and efavirenz C12 determined. The median efavirenz C12 was 2.41 mg/L (IQR, 1.93-3.14). In analysis of covariance models, patients with CYP2B6 516GT and TT genotypes compared to those with GG genotype had higher efavire ...[more]