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Quantitative genetic background of the host influences gut microbiomes in chickens.


ABSTRACT: Host genotype and gender are among the factors that influence the composition of gut microbiota. We studied the population structure of gut microbiota in two lines of chickens maintained under the same husbandry and dietary regimes. The lines, which originated from a common founder population, had undergone 54 generations of selection for high (HW) or low (LW) 56-day body weight, and now differ by more than 10-fold in body weight at selection age. Of 190 microbiome species, 68 were affected by genotype (line), gender, and genotype by gender interactions. Fifteen of the 68 species belong to Lactobacillus. Species affected by genotype, gender, and the genotype by gender interaction, were 29, 48, and 12, respectively. Species affected by gender were 30 and 17 in the HW and LW lines, respectively. Thus, under a common diet and husbandry host quantitative genotype and gender influenced gut microbiota composite.

SUBMITTER: Zhao L 

PROVIDER: S-EPMC3557447 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Quantitative genetic background of the host influences gut microbiomes in chickens.

Zhao Lele L   Wang Gang G   Siegel Paul P   He Chuan C   Wang Hezhong H   Zhao Wenjing W   Zhai Zhengxiao Z   Tian Fengwei F   Zhao Jianxin J   Zhang Hao H   Sun Zikui Z   Chen Wei W   Zhang Yan Y   Meng He H  

Scientific reports 20130129


Host genotype and gender are among the factors that influence the composition of gut microbiota. We studied the population structure of gut microbiota in two lines of chickens maintained under the same husbandry and dietary regimes. The lines, which originated from a common founder population, had undergone 54 generations of selection for high (HW) or low (LW) 56-day body weight, and now differ by more than 10-fold in body weight at selection age. Of 190 microbiome species, 68 were affected by g  ...[more]

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