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Differentiation of prions from L-type BSE versus sporadic Creutzfeldt-Jakob disease.


ABSTRACT: We compared transmission characteristics for prions from L-type bovine spongiform encephalopathy and MM2-cortical sporadic Creutzfeldt-Jakob disease in the Syrian golden hamster and an ovine prion protein-transgenic mouse line and isolated distinct prion strains. Our findings suggest the absence of a causal relationship between these diseases, but further investigation is warranted.

SUBMITTER: Nicot S 

PROVIDER: S-EPMC3557863 | biostudies-literature |

REPOSITORIES: biostudies-literature

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