Ontology highlight
ABSTRACT:
SUBMITTER: Imielinski M
PROVIDER: S-EPMC3557932 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Cell 20120901 6
Lung adenocarcinoma, the most common subtype of non-small cell lung cancer, is responsible for more than 500,000 deaths per year worldwide. Here, we report exome and genome sequences of 183 lung adenocarcinoma tumor/normal DNA pairs. These analyses revealed a mean exonic somatic mutation rate of 12.0 events/megabase and identified the majority of genes previously reported as significantly mutated in lung adenocarcinoma. In addition, we identified statistically recurrent somatic mutations in the ...[more]