Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex.
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ABSTRACT:
SUBMITTER: Hashimi H
PROVIDER: S-EPMC3558622 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Publications
Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex.
Hashimi Hassan H Zimmer Sara L SL Ammerman Michelle L ML Read Laurie K LK Lukeš Julius J
Trends in parasitology 20130108 2
Our understanding of kinetoplastid RNA (kRNA) editing has centered on this paradigm: guide RNAs (gRNAs) provide a blueprint for uridine insertion/deletion into mitochondrial mRNAs by the RNA editing core complex (RECC). The characterization of constituent subunits of the mitochondrial RNA-binding complex 1 (MRB1) implies that it too is vital to the editing process. The recently elucidated MRB1 architecture will be instrumental in putting functional data from individual subunits into context. Our ...[more]
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