Ontology highlight
ABSTRACT:
SUBMITTER: Mace EM
PROVIDER: S-EPMC3558996 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Mace Emily M EM Wu Winona W WW Ho Tina T Mann Shaina S SS Hsu Hsiang-Ting HT Orange Jordan S JS
Journal of immunology (Baltimore, Md. : 1950) 20121012 10
The formation of a dynamic, actin-rich immunological synapse (IS) and the polarization of cytolytic granules toward target cells are essential to the cytotoxic function of NK cells. Following polarization, lytic granules navigate through the pervasive actin network at the IS to degranulate and secrete their toxic contents onto target cells. We examined lytic granule motility and persistence at the cell cortex of activated human NK cells, using high-resolution total internal reflection microscopy ...[more]