Ontology highlight
ABSTRACT:
SUBMITTER: Kuzmiski JB
PROVIDER: S-EPMC3560287 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Kuzmiski J Brent JB Pittman Quentin J QJ Bains Jaideep S JS
Neuron 20090601 6
Neural networks that regulate an organism's internal environment must sense perturbations, respond appropriately, and then reset. These adaptations should be reflected as changes in the efficacy of the synapses that drive the final output of these homeostatic networks. Here we show that hemorrhage, an in vivo challenge to fluid homeostasis, induces LTD at glutamate synapses onto hypothalamic magnocellular neurosecretory cells (MNCs). LTD requires the activation of postsynaptic alpha2-adrenocepto ...[more]