Ontology highlight
ABSTRACT:
SUBMITTER: Lee MC
PROVIDER: S-EPMC2911980 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Lee Ming-Chia MC Yasuda Ryohei R Ehlers Michael D MD
Neuron 20100601 6
Optimal function of neuronal networks requires interplay between rapid forms of Hebbian plasticity and homeostatic mechanisms that adjust the threshold for plasticity, termed metaplasticity. Numerous forms of rapid synapse plasticity have been examined in detail. However, the rules that govern synaptic metaplasticity are much less clear. Here, we demonstrate a local subunit-specific switch in NMDA receptors that alternately primes or prevents potentiation at single synapses. Prolonged suppressio ...[more]