Ontology highlight
ABSTRACT:
SUBMITTER: Chuenkova MV
PROVIDER: S-EPMC2854580 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Chuenkova Marina V MV PereiraPerrin Mercio M
Science signaling 20091117 97
The parasite Trypanosoma cruzi, which causes Chagas' disease, differentiates in the cytosol of its host cell and then replicates and spreads infection, processes that require the long-term survival of the infected cells. Here, we show that in the cytosol, parasite-derived neurotrophic factor (PDNF), a trans-sialidase that is located on the surface of T. cruzi, is both a substrate and an activator of the serine-threonine kinase Akt, an antiapoptotic molecule. PDNF increases the expression of the ...[more]