Ontology highlight
ABSTRACT:
SUBMITTER: Previs MJ
PROVIDER: S-EPMC3561468 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20120823 6099
The heart's pumping capacity results from highly regulated interactions of actomyosin molecular motors. Mutations in the gene for a potential regulator of these motors, cardiac myosin-binding protein C (cMyBP-C), cause hypertrophic cardiomyopathy. However, cMyBP-C's ability to modulate cardiac contractility is not well understood. Using single-particle fluorescence imaging techniques, transgenic protein expression, proteomics, and modeling, we found that cMyBP-C slowed actomyosin motion generati ...[more]