Ontology highlight
ABSTRACT:
SUBMITTER: Marx VM
PROVIDER: S-EPMC3561906 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Marx Vanessa M VM Herbert Myles B MB Keitz Benjamin K BK Grubbs Robert H RH
Journal of the American Chemical Society 20121221 1
The first report of Z-selective macrocyclizations using a ruthenium-based metathesis catalyst is described. The selectivity for Z macrocycles is consistently high for a diverse set of substrates with a variety of functional groups and ring sizes. The same catalyst was also employed for the Z-selective ethenolysis of a mixture of E and Z macrocycles, providing the pure E isomer. Notably, an ethylene pressure of only 1 atm was required. These methodologies were successfully applied to the construc ...[more]