Ontology highlight
ABSTRACT:
SUBMITTER: Choo AM
PROVIDER: S-EPMC3562075 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Choo Anthony M AM Miller William J WJ Chen Yung-Chia YC Nibley Philip P Patel Tapan P TP Goletiani Cezar C Morrison Barclay B Kutzing Melinda K MK Firestein Bonnie L BL Sul Jai-Yoon JY Haydon Philip G PG Meaney David F DF
Brain : a journal of neurology 20130104 Pt 1
The recent public awareness of the incidence and possible long-term consequences of traumatic brain injury only heightens the need to develop effective approaches for treating this neurological disease. In this report, we identify a new therapeutic target for traumatic brain injury by studying the role of astrocytes, rather than neurons, after neurotrauma. We use in vivo multiphoton imaging and show that mechanical forces during trauma trigger intercellular calcium waves throughout the astrocyte ...[more]