Dataset Information

Allergies and risk of head and neck cancer: an original study plus meta-analysis.

ABSTRACT:

Background

Although the relationship between allergy and cancer has been investigated extensively, the role of allergy in head and neck cancer (HNC) appears less consistent. It is not clear whether allergies can independently influence the risk of HNC in the presence of known strong environmental risk factors, including consumption of alcohol, betel quid, and cigarette.

Methods

THE CURRENT PAPER REPORTS RESULTS FROM: 1) an original hospital-based case-control study, which included 252 incident cases of HNC and 236 controls frequency-matched to cases on sex and age; and 2) a meta-analysis combining the results of the current case-control study and 13 previously published studies (9 cohort studies with 727,569 subjects and 550 HNC outcomes and 5 case-control studies with 4,017 HNC cases and 10,928 controls).

Results

In the original case-control study, we observed a strong inverse association between allergies and HNC [odds ratio?=?0.41, 95% confidence interval (CI): 0.27-0.62]. The meta-analysis also indicated a statistically significant inverse association between HNC and allergies [meta-relative risk (RR)?=?0.76, 95% CI: 0.63-0.91], particularly strong for allergic rhinitis (meta-RR?=?0.55, 95% CI: 0.40-0.76). In addition, the inverse association between allergies and HNC was observed only among men (meta-RR?=?0.67, 95% CI: 0.54-0.84) but not among women (meta-RR?=?0.98, 95% CI: 0.81-1.18).

Conclusions

These findings suggest that immunity plays an influential role in the risk of HNC. Future studies investigating immune biomarkers, including cytokine profiles and genetic polymorphisms, are warranted to further delineate the relationship between allergies and HNC. Understanding the relationship between allergies and HNC may help devise effective strategies to reduce and treat HNC.

SUBMITTER: Hsiao JR

PROVIDER: S-EPMC3562357 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Allergies and risk of head and neck cancer: an original study plus meta-analysis.

Hsiao Jenn-Ren JR Ou Chun-Yen CY Lo Hung-I HI Huang Cheng-Chih CC Lee Wei-Ting WT Huang Jehn-Shyun JS Chen Ken-Chung KC Wong Tung-Yiu TY Tsai Sen-Tien ST Yen Chia-Jui CJ Wu Yuan-Hua YH Hsueh Wei-Ting WT Yang Ming-Wei MW Wu Shang-Yin SY Chang Jang-Yang JY Chang Kwang-Yu KY Lin Chen-Lin CL Wang Fang-Ting FT Wang Yi-Hui YH Weng Ya-Ling YL Yang Han-Chien HC Chang Jeffrey S JS

PloS one 20130201 2

<h4>Background</h4>Although the relationship between allergy and cancer has been investigated extensively, the role of allergy in head and neck cancer (HNC) appears less consistent. It is not clear whether allergies can independently influence the risk of HNC in the presence of known strong environmental risk factors, including consumption of alcohol, betel quid, and cigarette.<h4>Methods</h4>THE CURRENT PAPER REPORTS RESULTS FROM: 1) an original hospital-based case-control study, which included ...[more]

PMID: 23383309

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Project description:BackgroundMMP1 is an important member of the MMP endopeptidase family that plays a critical role in the development of head and neck cancer (HNC). Several studies have investigated the association between the MMP1 -1607 1G>2G polymorphism and risk of HNC, but their results have been inconsistent. Here, we conducted a meta-analysis to further explore the role of the MMP1 -1607 1G>2G polymorphism in HNC development.MethodsWe identified all eligible studies in the electronic databases of PubMed, ISI Web of Knowledge, MEDLINE, Embase, and Google Scholar (from January 2000 to June 2012). A meta-analysis was performed to evaluate the association between the MMP1 -1607 1G>2G polymorphism and risk of HNC by calculating odds ratios (OR) and 95% confidence interval (CIs).ResultsTwelve studies were included in this meta-analysis. In overall comparison, significant associations were found using the recessive and allelic contrast models (OR, 1.38; 95% CI, 1.07-1.79 and OR, 1.27; 95% CI, 1.05-1.53, respectively), but no association was detected using the dominant model. In the stratified analyses by several variables, significant associations were observed using the recessive, dominant, and allelic contrast models in the Asian population (OR, 1.64; 95% CI, 1.29-2.08; OR, 1.39; 95% CI, 1.06-1.82; and OR, 1.41; 95% CI, 1.21-1.65, respectively), European population (OR, 0.58; 95% CI, 0.40-0.84; OR, 0.64; 95% CI, 0.44-0.92; and OR, 0.68; 95% CI, 0.54-0.85, respectively), and population-based subgroup (OR, 1.24; 95% CI,1.05-1.47; OR,1.48; 95% CI,1.04-2.12; and OR, 1.22; 95% CI, 1.07-1.38, respectively). Furthermore, significant associations were detected in oral cavity cancer and nasopharyngeal cancer under the recessive model.ConclusionOur results suggest that the MMP1 -1607 1G>2G polymorphism is associated with risk of HNC and that it plays different roles in Asian and European populations. Further studies with large sample size are needed to validate our findings.

Dataset Information

Allergies and risk of head and neck cancer: an original study plus meta-analysis.

Background

Methods

Results

Conclusions

Publications

Allergies and risk of head and neck cancer: an original study plus meta-analysis.

Similar Datasets

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