Dataset Information

GSTM3 A/B polymorphism and risk for head and neck cancer: a meta-analysis.

ABSTRACT: BACKGROUND: Glutathione S-transferase M3 (GSTM3) is an important member of the GSTs that plays a critical role in the development of head and neck cancer (HNC). Several studies have investigated between the GSTM3 A/B polymorphism and risk of HNC, however, the results remain controversial. The aim of this meta-analysis is to evaluate the association between the GSTM3 A/B polymorphism and the risk of HNC. METHODS: All eligible case-control studies published up to July 2013 were identified by searching PubMed and Web of Science. The HNC risk associated with the GSTM3 A/B polymorphism was estimated for each study by odds ratios (OR) together with its 95% confidence interval (CI), respectively. RESULTS: Fourteen studies from ten publications with 2110 patients and 2259 controls were included. Overall, the GSTM3 A/B polymorphism was associated with a decreased risk of HNC using the dominant model, homozygote comparison model and heterozygote comparison model (OR?=?0.82, 95%CI: 0.71-0.94; OR?=?0.67, 95%CI: 0.49-0.94; and OR?=?0.84, 95%CI: 0.73-0.97, respectively); besides, in stratification analyses by ethnicity, similar results were observed in Caucasian populations. Stratification by tumor site indicated that the GSTM3 polymorphism was associated with a decreased risk of laryngeal cancer under recessive model and homozygote comparison (OR?=?0.52, 95%CI: 0.30-0.89; and OR?=?0.50, 95%CI: 0.29-0.87, respectively); By stratifying source of control, decreased cancer risk was observed in hospital-based population under all genetic models (OR?=?0.67, 95%CI: 0.56-0.81 for the dominant model; OR?=?0.66, 95%CI: 0.46-0.95 for the recessive model; OR?=?0.55, 95%CI: 0.37-0.83 for the homozygote comparison model, and OR?=?0.70, 95%CI: 0.58-0.84 for the heterozygote comparison model). CONCLUSIONS: This meta-analysis suggests that the GSTM3 A/B polymorphism may be an important protective factor for HNC, especially of laryngeal cancer and Caucasian populations.

SUBMITTER: Xu Y

PROVIDER: S-EPMC3885523 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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GSTM3 A/B polymorphism and risk for head and neck cancer: a meta-analysis.

Xu Yu Y Wang Jun J Dong Weiguo W

PloS one 20140108 1

<h4>Background</h4>Glutathione S-transferase M3 (GSTM3) is an important member of the GSTs that plays a critical role in the development of head and neck cancer (HNC). Several studies have investigated between the GSTM3 A/B polymorphism and risk of HNC, however, the results remain controversial. The aim of this meta-analysis is to evaluate the association between the GSTM3 A/B polymorphism and the risk of HNC.<h4>Methods</h4>All eligible case-control studies published up to July 2013 were identi ...[more]

PMID: 24416175

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Project description:BACKGROUND: MMP1 is an important member of the MMP endopeptidase family that plays a critical role in the development of head and neck cancer (HNC). Several studies have investigated the association between the MMP1 -1607 1G>2G polymorphism and risk of HNC, but their results have been inconsistent. Here, we conducted a meta-analysis to further explore the role of the MMP1 -1607 1G>2G polymorphism in HNC development. METHODS: We identified all eligible studies in the electronic databases of PubMed, ISI Web of Knowledge, MEDLINE, Embase, and Google Scholar (from January 2000 to June 2012). A meta-analysis was performed to evaluate the association between the MMP1 -1607 1G>2G polymorphism and risk of HNC by calculating odds ratios (OR) and 95% confidence interval (CIs). RESULTS: Twelve studies were included in this meta-analysis. In overall comparison, significant associations were found using the recessive and allelic contrast models (OR, 1.38; 95% CI, 1.07-1.79 and OR, 1.27; 95% CI, 1.05-1.53, respectively), but no association was detected using the dominant model. In the stratified analyses by several variables, significant associations were observed using the recessive, dominant, and allelic contrast models in the Asian population (OR, 1.64; 95% CI, 1.29-2.08; OR, 1.39; 95% CI, 1.06-1.82; and OR, 1.41; 95% CI, 1.21-1.65, respectively), European population (OR, 0.58; 95% CI, 0.40-0.84; OR, 0.64; 95% CI, 0.44-0.92; and OR, 0.68; 95% CI, 0.54-0.85, respectively), and population-based subgroup (OR, 1.24; 95% CI,1.05-1.47; OR,1.48; 95% CI,1.04-2.12; and OR, 1.22; 95% CI, 1.07-1.38, respectively). Furthermore, significant associations were detected in oral cavity cancer and nasopharyngeal cancer under the recessive model. CONCLUSION: Our results suggest that the MMP1 -1607 1G>2G polymorphism is associated with risk of HNC and that it plays different roles in Asian and European populations. Further studies with large sample size are needed to validate our findings.

Dataset Information

GSTM3 A/B polymorphism and risk for head and neck cancer: a meta-analysis.

Publications

GSTM3 A/B polymorphism and risk for head and neck cancer: a meta-analysis.

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