Ontology highlight
ABSTRACT:
SUBMITTER: Dong B
PROVIDER: S-EPMC3562448 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Dong Bo B Kakihara Ken K Otani Tetsuhisa T Wada Housei H Hayashi Shigeo S
Nature communications 20130101
Apical extracellular matrix filling the lumen controls the morphology and geometry of epithelial tubes during development, yet the regulation of luminal protein composition and its role in tube morphogenesis are not well understood. Here we show that an endosomal-retrieval machinery consisting of Rab9, retromer and actin nucleator WASH (Wiskott-Aldrich Syndrome Protein and SCAR Homolog) regulates selective recycling of the luminal protein Serpentine in the Drosophila trachea. Secreted Serpentine ...[more]