Ontology highlight
ABSTRACT:
SUBMITTER: Kim MJ
PROVIDER: S-EPMC6251589 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Human molecular genetics 20170201 4
TMEM230 is a newly identified Parkinson's disease (PD) gene encoding a transmembrane protein whose cellular and pathogenic roles remain largely unknown. Here, we demonstrate that loss of TMEM230 disrupts retromer cargo CI-M6PR (cation-independent mannose 6-phosphate receptor) trafficking and autophagic cargo degradation rates. TMEM230 depletion further inhibits extracellular secretion of the autophagic cargo p62 and immature lysosomal hydrolases in Golgi-derived vesicles leading to their intrace ...[more]