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Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.

ABSTRACT: We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 x 10(-10)) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 x 10(-15)) and rs445114[T] (OR = 1.14, P = 4.7 x 10(-10)), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 x 10(-11)) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 x 10(-12)). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population.

SUBMITTER: Gudmundsson J 

PROVIDER: S-EPMC3562712 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature

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Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.

Gudmundsson Julius J   Sulem Patrick P   Gudbjartsson Daniel F DF   Blondal Thorarinn T   Gylfason Arnaldur A   Agnarsson Bjarni A BA   Benediktsdottir Kristrun R KR   Magnusdottir Droplaug N DN   Orlygsdottir Gudbjorg G   Jakobsdottir Margret M   Stacey Simon N SN   Sigurdsson Asgeir A   Wahlfors Tiina T   Tammela Teuvo T   Breyer Joan P JP   McReynolds Kate M KM   Bradley Kevin M KM   Saez Berta B   Godino Javier J   Navarrete Sebastian S   Fuertes Fernando F   Murillo Laura L   Polo Eduardo E   Aben Katja K KK   van Oort Inge M IM   Suarez Brian K BK   Helfand Brian T BT   Kan Donghui D   Zanon Carlo C   Frigge Michael L ML   Kristjansson Kristleifur K   Gulcher Jeffrey R JR   Einarsson Gudmundur V GV   Jonsson Eirikur E   Catalona William J WJ   Mayordomo Jose I JI   Kiemeney Lambertus A LA   Smith Jeffrey R JR   Schleutker Johanna J   Barkardottir Rosa B RB   Kong Augustine A   Thorsteinsdottir Unnur U   Rafnar Thorunn T   Stefansson Kari K  

Nature genetics 20090920 10

We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 x 10(-10)) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 x 10(-15)) and rs445114[T] (OR = 1.14, P = 4.7 x 10(-10)), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 x 10(-11)) on 19q13.2. We also refined a previous association signal on 11  ...[more]

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