Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
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ABSTRACT:
SUBMITTER: Garcia-Closas M
PROVIDER: S-EPMC3771695 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
Garcia-Closas Montserrat M Couch Fergus J FJ Lindstrom Sara S Michailidou Kyriaki K Schmidt Marjanka K MK Brook Mark N MN Orr Nick N Rhie Suhn Kyong SK Riboli Elio E Feigelson Heather S HS Le Marchand Loic L Buring Julie E JE Eccles Diana D Miron Penelope P Fasching Peter A PA Brauch Hiltrud H Chang-Claude Jenny J Carpenter Jane J Godwin Andrew K AK Nevanlinna Heli H Giles Graham G GG Cox Angela A Hopper John L JL Bolla Manjeet K MK Wang Qin Q Dennis Joe J Dicks Ed E Howat Will J WJ Schoof Nils N Bojesen Stig E SE Lambrechts Diether D Broeks Annegien A Andrulis Irene L IL Guénel Pascal P Burwinkel Barbara B Sawyer Elinor J EJ Hollestelle Antoinette A Fletcher Olivia O Winqvist Robert R Brenner Hermann H Mannermaa Arto A Hamann Ute U Meindl Alfons A Lindblom Annika A Zheng Wei W Devillee Peter P Goldberg Mark S MS Lubinski Jan J Kristensen Vessela V Swerdlow Anthony A Anton-Culver Hoda H Dörk Thilo T Muir Kenneth K Matsuo Keitaro K Wu Anna H AH Radice Paolo P Teo Soo Hwang SH Shu Xiao-Ou XO Blot William W Kang Daehee D Hartman Mikael M Sangrajrang Suleeporn S Shen Chen-Yang CY Southey Melissa C MC Park Daniel J DJ Hammet Fleur F Stone Jennifer J Veer Laura J Van't LJ Rutgers Emiel J EJ Lophatananon Artitaya A Stewart-Brown Sarah S Siriwanarangsan Pornthep P Peto Julian J Schrauder Michael G MG Ekici Arif B AB Beckmann Matthias W MW Dos Santos Silva Isabel I Johnson Nichola N Warren Helen H Tomlinson Ian I Kerin Michael J MJ Miller Nicola N Marme Federick F Schneeweiss Andreas A Sohn Christof C Truong Therese T Laurent-Puig Pierre P Kerbrat Pierre P Nordestgaard Børge G BG Nielsen Sune F SF Flyger Henrik H Milne Roger L RL Perez Jose Ignacio Arias JI Menéndez Primitiva P Müller Heiko H Arndt Volker V Stegmaier Christa C Lichtner Peter P Lochmann Magdalena M Justenhoven Christina C Ko Yon-Dschun YD Muranen Taru A TA Aittomäki Kristiina K Blomqvist Carl C Greco Dario D Heikkinen Tuomas T Ito Hidemi H Iwata Hiroji H Yatabe Yasushi Y Antonenkova Natalia N NN Margolin Sara S Kataja Vesa V Kosma Veli-Matti VM Hartikainen Jaana M JM Balleine Rosemary R Tseng Chiu-Chen CC Berg David Van Den DV Stram Daniel O DO Neven Patrick P Dieudonné Anne-Sophie AS Leunen Karin K Rudolph Anja A Nickels Stefan S Flesch-Janys Dieter D Peterlongo Paolo P Peissel Bernard B Bernard Loris L Olson Janet E JE Wang Xianshu X Stevens Kristen K Severi Gianluca G Baglietto Laura L McLean Catriona C Coetzee Gerhard A GA Feng Ye Y Henderson Brian E BE Schumacher Fredrick F Bogdanova Natalia V NV Labrèche France F Dumont Martine M Yip Cheng Har CH Taib Nur Aishah Mohd NA Cheng Ching-Yu CY Shrubsole Martha M Long Jirong J Pylkäs Katri K Jukkola-Vuorinen Arja A Kauppila Saila S Knight Julia A JA Glendon Gord G Mulligan Anna Marie AM Tollenaar Robertus A E M RA Seynaeve Caroline M CM Kriege Mieke M Hooning Maartje J MJ van den Ouweland Ans M W AM van Deurzen Carolien H M CH Lu Wei W Gao Yu-Tang YT Cai Hui H Balasubramanian Sabapathy P SP Cross Simon S SS Reed Malcolm W R MW Signorello Lisa L Cai Qiuyin Q Shah Mitul M Miao Hui H Chan Ching Wan CW Chia Kee Seng KS Jakubowska Anna A Jaworska Katarzyna K Durda Katarzyna K Hsiung Chia-Ni CN Wu Pei-Ei PE Yu Jyh-Cherng JC Ashworth Alan A Jones Michael M Tessier Daniel C DC González-Neira Anna A Pita Guillermo G Alonso M Rosario MR Vincent Daniel D Bacot Francois F Ambrosone Christine B CB Bandera Elisa V EV John Esther M EM Chen Gary K GK Hu Jennifer J JJ Rodriguez-Gil Jorge L JL Bernstein Leslie L Press Michael F MF Ziegler Regina G RG Millikan Robert M RM Deming-Halverson Sandra L SL Nyante Sarah S Ingles Sue A SA Waisfisz Quinten Q Tsimiklis Helen H Makalic Enes E Schmidt Daniel D Bui Minh M Gibson Lorna L Müller-Myhsok Bertram B Schmutzler Rita K RK Hein Rebecca R Dahmen Norbert N Beckmann Lars L Aaltonen Kirsimari K Czene Kamila K Irwanto Astrid A Liu Jianjun J Turnbull Clare C Rahman Nazneen N Meijers-Heijboer Hanne H Uitterlinden Andre G AG Rivadeneira Fernando F Olswold Curtis C Slager Susan S Pilarski Robert R Ademuyiwa Foluso F Konstantopoulou Irene I Martin Nicholas G NG Montgomery Grant W GW Slamon Dennis J DJ Rauh Claudia C Lux Michael P MP Jud Sebastian M SM Bruning Thomas T Weaver Joellen J Sharma Priyanka P Pathak Harsh H Tapper Will W Gerty Sue S Durcan Lorraine L Trichopoulos Dimitrios D Tumino Rosario R Peeters Petra H PH Kaaks Rudolf R Campa Daniele D Canzian Federico F Weiderpass Elisabete E Johansson Mattias M Khaw Kay-Tee KT Travis Ruth R Clavel-Chapelon Françoise F Kolonel Laurence N LN Chen Constance C Beck Andy A Hankinson Susan E SE Berg Christine D CD Hoover Robert N RN Lissowska Jolanta J Figueroa Jonine D JD Chasman Daniel I DI Gaudet Mia M MM Diver W Ryan WR Willett Walter C WC Hunter David J DJ Simard Jacques J Benitez Javier J Dunning Alison M AM Sherman Mark E ME Chenevix-Trench Georgia G Chanock Stephen J SJ Hall Per P Pharoah Paul D P PD Vachon Celine C Easton Douglas F DF Haiman Christopher A CA Kraft Peter P
Nature genetics 20130401 4
Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cas ...[more]