Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Closas M
PROVIDER: S-EPMC3771695 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Nature genetics 20130401 4
Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cas ...[more]