Ontology highlight
ABSTRACT:
SUBMITTER: La Regina G
PROVIDER: S-EPMC3563301 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20121227 1
New arylthioindole derivatives having different cyclic substituents at position 2 of the indole were synthesized as anticancer agents. Several compounds inhibited tubulin polymerization at submicromolar concentration and inhibited cell growth at low nanomolar concentrations. Compounds 18 and 57 were superior to the previously synthesized 5. Compound 18 was exceptionally potent as an inhibitor of cell growth: it showed IC₅₀ = 1.0 nM in MCF-7 cells, and it was uniformly active in the whole panel o ...[more]