Ontology highlight
ABSTRACT:
SUBMITTER: Rosen MJ
PROVIDER: S-EPMC3563472 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
BMC bioinformatics 20121031
<h4>Background</h4>PCR amplification and high-throughput sequencing theoretically enable the characterization of the finest-scale diversity in natural microbial and viral populations, but each of these methods introduces random errors that are difficult to distinguish from genuine biological diversity. Several approaches have been proposed to denoise these data but lack either speed or accuracy.<h4>Results</h4>We introduce a new denoising algorithm that we call DADA (Divisive Amplicon Denoising ...[more]