Ontology highlight
ABSTRACT:
SUBMITTER: Kleine Bardenhorst S
PROVIDER: S-EPMC8762370 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Kleine Bardenhorst Sven S Vital Marius M Karch André A Rübsamen Nicole N
Computational and structural biotechnology journal 20220110
The quantification of richness within a sample-either measured as the number of observed species or approximated by estimation-is a common first step in microbiome studies and is known to be highly dependent on sequencing depth, which itself is highly variable between samples. Rarefaction curves serve as a tool to investigate this dependency and it is often argued that after rarefying data-sub-sampling to an equal sequencing depth-richness estimates no longer depend on sequencing depth. However, ...[more]