CPMV-DOX delivers.
Ontology highlight
ABSTRACT:
SUBMITTER: Aljabali AA
PROVIDER: S-EPMC3564650 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
CPMV-DOX delivers.
Aljabali Alaa A A AA Shukla Sourabh S Lomonossoff George P GP Steinmetz Nicole F NF Evans David J DJ
Molecular pharmaceutics 20120806 1
The plant virus, Cowpea mosaic virus (CPMV), is developed as a carrier of the chemotherapeutic drug doxorubicin (DOX). CPMV-DOX conjugate, in which eighty DOX molecules are covalently bound to external surface carboxylates of the viral nanoparticle (VNP), shows greater cytotoxicity than free DOX toward HeLa cells when administered at low dosage. At higher concentrations, CPMV-DOX cytotoxicity is time-delayed. The CPMV conjugate is targeted to the endolysosomal compartment of the cells, in which ...[more]
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