Endocytic uptake pathways utilized by CPMV nanoparticles.
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ABSTRACT:
SUBMITTER: Plummer EM
PROVIDER: S-EPMC3590106 | biostudies-other | 2013 Jan
REPOSITORIES: biostudies-other
Publications
Endocytic uptake pathways utilized by CPMV nanoparticles.
Plummer Emily M EM Manchester Marianne M
Molecular pharmaceutics 20120920 1
Cowpea mosaic virus (CPMV) has been used as a nanoparticle platform for biomedical applications including vaccine development, in vivo vascular imaging, and tissue-targeted delivery. A better understanding of the mechanisms of CPMV targeting and cell internalization would enable enhanced targeting and more effective delivery. Previous studies showed that, following binding and internalization by mammalian cells, CPMV localizes in a perinuclear late-endosome compartment where it remains for as lo ...[more]
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