Ontology highlight
ABSTRACT:
SUBMITTER: Raeder MB
PROVIDER: S-EPMC3564856 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Raeder Maria B MB Birkeland Even E Trovik Jone J Krakstad Camilla C Shehata Shyemaa S Schumacher Steven S Zack Travis I TI Krohn Antje A Werner Henrica Mj HM Moody Susan E SE Wik Elisabeth E Stefansson Ingunn M IM Holst Frederik F Oyan Anne M AM Tamayo Pablo P Mesirov Jill P JP Kalland Karl H KH Akslen Lars A LA Simon Ronald R Beroukhim Rameen R Salvesen Helga B HB
PloS one 20130205 2
Chromosome 8q24 is the most commonly amplified region across multiple cancer types, and the typical length of the amplification suggests that it may target additional genes to MYC. To explore the roles of the genes most frequently included in 8q24 amplifications, we analyzed the relation between copy number alterations and gene expression in three sets of endometrial cancers (N = 252); and in glioblastoma, ovarian, and breast cancers profiled by TCGA. Among the genes neighbouring MYC, expression ...[more]