Ontology highlight
ABSTRACT:
SUBMITTER: Mariner PD
PROVIDER: S-EPMC3565235 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Mariner Peter D PD Wudel Justin M JM Miller David E DE Genova E Erin EE Streubel Sven-Olrik SO Anseth Kristi S KS
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20121015 3
Medtronic's INFUSE Bone Graft provides surgeons with a potent tool for stimulating bone formation. Current delivery vehicles that rely on Absorbable Collagen Sponges (ACS) require excessive quantities of the active ingredient in INFUSE, recombinant human Bone Morphogenic Protein-2 (rhBMP2), to achieve physiologically relevant concentrations of the growth factor, driving up the cost of the product and increasing the likelihood of undesirable side effects in neighboring tissues. We demonstrate tha ...[more]