Ontology highlight
ABSTRACT:
SUBMITTER: Konieczna IM
PROVIDER: S-EPMC3566349 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Konieczna Iwona M IM Panuganti Swapna S DeLuca Teresa A TA Papoutsakis E Terry ET Eklund Elizabeth A EA Miller William M WM
Blood cells, molecules & diseases 20121221 3
Elucidating ways to enhance megakaryopoiesis in vivo would have therapeutic applications for thrombocytopenia and transfusion medicine. Nicotinamide has been shown to enhance endomitosis in megakaryocytes cultured in vitro, suggesting that it may be beneficial for the production of platelets in culture. We hypothesized that regular injections of nicotinamide in mice would also increase platelets in vivo. However, we found that platelet counts were reduced by about 25% with daily injections of ni ...[more]