Ontology highlight
ABSTRACT:
SUBMITTER: Muroi S
PROVIDER: S-EPMC3566579 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Muroi Sawako S Tanaka Hirokazu H Miyamoto Chizuko C Taniuchi Ichiro I
Journal of immunology (Baltimore, Md. : 1950) 20130111 4
Differentiation of MHC class II-selected thymocytes toward the CD4(+) helper lineage depends on function of the transcription factor ThPOK, whose expression is repressed in CD8(+) cytotoxic lineage cells by a transcriptional silencer activity within the distal regulatory element (DRE) in the Thpok gene. Interestingly, the DRE also functions as a transcriptional enhancer. However, how the DRE exerts such dual functionality remains obscure. In this study, we dissected the DRE and identified DNA se ...[more]