Ontology highlight
ABSTRACT:
SUBMITTER: Liew CW
PROVIDER: S-EPMC3567215 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Liew Chong Wee CW Boucher Jeremie J Cheong Jit Kong JK Vernochet Cecile C Koh Ho-Jin HJ Mallol Cristina C Townsend Kristy K Langin Dominique D Kawamori Dan D Hu Jiang J Tseng Yu-Hua YH Hellerstein Marc K MK Farmer Stephen R SR Goodyear Laurie L Doria Alessandro A Blüher Matthias M Hsu Stephen I-Hong SI Kulkarni Rohit N RN
Nature medicine 20130106 2
Obesity develops as a result of altered energy homeostasis favoring fat storage. Here we describe a new transcription co-regulator for adiposity and energy metabolism, SERTA domain containing 2 (TRIP-Br2, also called SERTAD2). TRIP-Br2-null mice are resistant to obesity and obesity-related insulin resistance. Adipocytes of these knockout mice showed greater stimulated lipolysis secondary to enhanced expression of hormone sensitive lipase (HSL) and β3-adrenergic (Adrb3) receptors. The knockout mi ...[more]