Ontology highlight
ABSTRACT:
SUBMITTER: Qiang G
PROVIDER: S-EPMC4848483 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Qiang Guifen G Kong Hyerim Whang HW Fang Difeng D McCann Maximilian M Yang Xiuying X Du Guanhua G Blüher Matthias M Zhu Jinfang J Liew Chong Wee CW
Nature communications 20160425
The intimate link between location of fat accumulation and metabolic disease risk and depot-specific differences is well established, but how these differences between depots are regulated at the molecular level remains largely unclear. Here we show that TRIP-Br2 mediates endoplasmic reticulum (ER) stress-induced inflammatory responses in visceral fat. Using in vitro, ex vivo and in vivo approaches, we demonstrate that obesity-induced circulating factors upregulate TRIP-Br2 specifically in visce ...[more]