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Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure.

ABSTRACT: Here we introduce tethered capsule endomicroscopy, which involves swallowing an optomechanically engineered pill that captures cross-sectional microscopic images of the gut wall at 30 ?m (lateral) × 7 ?m (axial) resolution as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural images of the upper gastrointestinal tract in a simple and painless procedure, opening up new opportunities for screening for internal diseases.

SUBMITTER: Gora MJ 

PROVIDER: S-EPMC3567218 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure.

Gora Michalina J MJ   Sauk Jenny S JS   Carruth Robert W RW   Gallagher Kevin A KA   Suter Melissa J MJ   Nishioka Norman S NS   Kava Lauren E LE   Rosenberg Mireille M   Bouma Brett E BE   Tearney Guillermo J GJ  

Nature medicine 20130113 2

Here we introduce tethered capsule endomicroscopy, which involves swallowing an optomechanically engineered pill that captures cross-sectional microscopic images of the gut wall at 30 μm (lateral) × 7 μm (axial) resolution as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural images of the upper gastrointestinal tract in a simple and painless procedure, opening up new opportunities for screening for inter  ...[more]

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