Ontology highlight
ABSTRACT:
SUBMITTER: Cosgrove C
PROVIDER: S-EPMC3567342 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Cosgrove Cormac C Ussher James E JE Rauch Andri A Gärtner Kathleen K Kurioka Ayako A Hühn Michael H MH Adelmann Krista K Kang Yu-Hoi YH Fergusson Joannah R JR Simmonds Peter P Goulder Philip P Hansen Ted H TH Fox Julie J Günthard Huldrych F HF Khanna Nina N Powrie Fiona F Steel Alan A Gazzard Brian B Phillips Rodney E RE Frater John J Uhlig Holm H Klenerman Paul P
Blood 20121218 6
HIV infection is associated with immune dysfunction, perturbation of immune-cell subsets and opportunistic infections. CD161++ CD8+ T cells are a tissue-infiltrating population that produce IL17A, IL22, IFN, and TNFα, cytokines important in mucosal immunity. In adults they dominantly express the semi-invariant TCR Vα7.2, the canonical feature of mucosal associated invariant T (MAIT) cells and have been recently implicated in host defense against pathogens. We analyzed the frequency and function ...[more]