Ontology highlight
ABSTRACT:
SUBMITTER: Lal KG
PROVIDER: S-EPMC7764746 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Lal Kerri G KG Phuang-Ngern Yuwadee Y Suhkumvittaya Suchada S Leeansyah Edwin E Alrubayyi Aljawharah A Dias Joana J Waickman Adam A Kim Dohoon D Kroon Eugène E Pinyakorn Suteeraporn S Eller Leigh Anne LA Maciel Milton M Rerknimitr Rungsun R Chomchey Nitiya N Phanuphak Nittaya N de Souza Mark S S MSS Nitayaphan Sorachai S Ake Julie A JA Vasan Sandhya S Robb Merlin L ML Ananworanich Jintanat J Sandberg Johan K JK Schuetz Alexandra A Eller Michael A MA Paquin-Proulx Dominic D
Viruses 20201211 12
CD161 expression on CD4<sup>+</sup> T cells is associated with a Th17 functional phenotype, as well as with an innate capacity to respond to interleukin (IL)-12 and IL-18 without T cell receptor (TCR) stimulation. Chronic HIV-1 infection is associated with loss of the CD161<sup>+</sup> CD4 T cell population, and non-human primate studies suggest that their depletion is associated with disease progression. However, the dynamics of the CD161<sup>+</sup> CD4<sup>+</sup> T cell population during acu ...[more]