Ontology highlight
ABSTRACT:
SUBMITTER: Choi HS
PROVIDER: S-EPMC3568187 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Choi Hak Soo HS Gibbs Summer L SL Lee Jeong Heon JH Kim Soon Hee SH Ashitate Yoshitomo Y Liu Fangbing F Hyun Hoon H Park GwangLi G Xie Yang Y Bae Soochan S Henary Maged M Frangioni John V JV
Nature biotechnology 20130106 2
The signal-to-background ratio (SBR) is the key determinant of sensitivity, detectability and linearity in optical imaging. As signal strength is often constrained by fundamental limits, background reduction becomes an important approach for improving the SBR. We recently reported that a zwitterionic near-infrared (NIR) fluorophore, ZW800-1, exhibits low background. Here we show that this fluorophore provides a much-improved SBR when targeted to cancer cells or proteins by conjugation with a cyc ...[more]