Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC4338581 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Zhang Xuan X Bresee Jamee J Fields Gregg B GB Edwards W Barry WB
Bioorganic & medicinal chemistry letters 20140705 16
The gelatinase members of the MMP family have consistently been associated with tumor invasiveness, which make them an attractive target for molecular imaging. We report new activatable proteolytic optical imaging agents that consist of triple-helical peptide (THP) conjugates, with high specificity to the gelatinases, bearing quenched cypate dyes. With quenching efficiencies up to 51%, the amplified fluorescence signal upon cypate3-THP hydrolysis by the gelatinases (kcat/KM values of 6.4×10(3) M ...[more]