Ontology highlight
ABSTRACT:
SUBMITTER: Reilly MP
PROVIDER: S-EPMC3568699 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Reilly Michael P MP Sinha Uma U André Pierrette P Taylor Scott M SM Pak Yvonne Y Deguzman Francis R FR Nanda Nisha N Pandey Anjali A Stolla Moritz M Bergmeier Wolfgang W McKenzie Steven E SE
Blood 20101118 7
Heparin-induced thrombocytopenia (HIT) is a major cause of morbidity and mortality resulting from the associated thrombosis. Extensive studies using our transgenic mouse model of HIT have shown that antibodies reactive with heparin-platelet factor 4 complexes lead to FcγRIIA-mediated platelet activation in vitro as well as thrombocytopenia and thrombosis in vivo. We tested PRT-060318 (PRT318), a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment. PRT318 complet ...[more]