Ontology highlight
ABSTRACT:
SUBMITTER: Alinari L
PROVIDER: S-EPMC3568700 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Alinari Lapo L Mahoney Emilia E Patton John J Zhang Xiaoli X Huynh Lenguyen L Earl Christian T CT Mani Rajeswaran R Mao Yicheng Y Yu Bo B Quinion Carl C Towns William H WH Chen Ching-Shih CS Goldenberg David M DM Blum Kristie A KA Byrd John C JC Muthusamy Natarajan N Praetorius-Ibba Mette M Baiocchi Robert A RA
Blood 20111031 26
Mantle cell lymphoma (MCL) is an aggressive B-cell malignancy with a short median survival despite multimodal therapy. FTY720, an immunosuppressive drug approved for the treatment of multiple sclerosis, promotes MCL cell death concurrent with down-modulation of phospho-Akt and cyclin D1 and subsequent cell-cycle arrest. However, the mechanism of FTY720-mediated MCL cell death remains to be fully clarified. In the present study, we show features of autophagy blockage by FTY720 treatment, includin ...[more]