Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC3569089 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Wang Shiyu S Chen Zhouji Z Lam Vivian V Han Jaeseok J Hassler Justin J Finck Brian N BN Davidson Nicholas O NO Kaufman Randal J RJ
Cell metabolism 20121001 4
The unfolded protein response (UPR) is a signaling pathway required to maintain endoplasmic reticulum (ER) homeostasis and hepatic lipid metabolism. Here, we identify an essential role for the inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α)-X box binding protein 1 (XBP1) arm of the UPR in regulation of hepatic very low-density lipoprotein (VLDL) assembly and secretion. Hepatocyte-specific deletion of Ire1α reduces lipid partitioning into the ER lumen and impairs the assembly ...[more]