Ontology highlight
ABSTRACT:
SUBMITTER: Grandjean JMD
PROVIDER: S-EPMC7502540 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Grandjean Julia M D JMD Madhavan Aparajita A Cech Lauren L Seguinot Bryan O BO Paxman Ryan J RJ Smith Emery E Scampavia Louis L Powers Evan T ET Cooley Christina B CB Plate Lars L Spicer Timothy P TP Kelly Jeffery W JW Wiseman R Luke RL
Nature chemical biology 20200720 10
Activation of the IRE1/XBP1s signaling arm of the unfolded protein response (UPR) is a promising strategy to correct defects in endoplasmic reticulum (ER) proteostasis implicated in diverse diseases. However, no pharmacologic activators of this pathway identified to date are suitable for ER proteostasis remodeling through selective activation of IRE1/XBP1s signaling. Here, we use high-throughput screening to identify non-toxic compounds that induce ER proteostasis remodeling through IRE1/XBP1s a ...[more]