Ontology highlight
ABSTRACT:
SUBMITTER: Indrieri A
PROVIDER: S-EPMC3569643 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Indrieri Alessia A Conte Ivan I Chesi Giancarlo G Romano Alessia A Quartararo Jade J Tatè Rosarita R Ghezzi Daniele D Zeviani Massimo M Goffrini Paola P Ferrero Ileana I Bovolenta Paola P Franco Brunella B
EMBO molecular medicine 20130122 2
Mitochondrial-dependent (intrinsic) programmed cell death (PCD) is an essential homoeostatic mechanism that selects bioenergetically proficient cells suitable for tissue/organ development. However, the link between mitochondrial dysfunction, intrinsic apoptosis and developmental anomalies has not been demonstrated to date. Now we provide the evidence that non-canonical mitochondrial dependent apoptosis explains the phenotype of microphthalmia with linear skin lesions (MLS), an X-linked developme ...[more]