Ontology highlight
ABSTRACT:
SUBMITTER: Lu M
PROVIDER: S-EPMC3841111 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Lu Ming M Hu Xi-Han XH Li Qin Q Xiong Ying Y Hu Guang-Jing GJ Xu Jia-Jia JJ Zhao Xiao-Nan XN Wei Xi-Xiao XX Chang Catherine C Y CC Liu Yin-Kun YK Nan Fa-Jun FJ Li Jia J Chang Ta-Yuan TY Song Bao-Liang BL Li Bo-Liang BL
Journal of molecular cell biology 20131026 6
The liver plays a central role in cholesterol homeostasis. It exclusively receives and metabolizes oxysterols, which are important metabolites of cholesterol and are more cytotoxic than free cholesterol, from all extrahepatic tissues. Hepatocellular carcinomas (HCCs) impair certain liver functions and cause pathological alterations in many processes including cholesterol metabolism. However, the link between an altered cholesterol metabolism and HCC development is unclear. Human ACAT2 is abundan ...[more]