Hepatitis C genotype 1 mosaic vaccines are immunogenic in mice and induce stronger T-cell responses than natural strains.
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ABSTRACT:
SUBMITTER: Yusim K
PROVIDER: S-EPMC3571268 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Publications
Hepatitis C genotype 1 mosaic vaccines are immunogenic in mice and induce stronger T-cell responses than natural strains.
Yusim Karina K Dilan Rebecca R Borducchi Erica E Stanley Kelly K Giorgi Elena E Fischer William W Theiler James J Marcotrigiano Joseph J Korber Bette B Barouch Dan H DH
Clinical and vaccine immunology : CVI 20121205 2
Despite improved hepatitis C virus (HCV) treatments, vaccines remain an effective and economic option for curtailing the epidemic. Mosaic protein HCV genotype 1 vaccine candidates designed to address HCV diversity were immunogenic in mice. They elicited stronger T-cell responses to NS3-NS4a and E1-E2 proteins than did natural strains, as assessed with vaccine-matched peptides. ...[more]
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