Ontology highlight
ABSTRACT:
SUBMITTER: Gebre MS
PROVIDER: S-EPMC9340693 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Gebre Makda S MS Rauch Susanne S Roth Nicole N Gergen Janina J Yu Jingyou J Liu Xiaowen X Cole Andrew C AC Mueller Stefan O SO Petsch Benjamin B Barouch Dan H DH
NPJ vaccines 20220801 1
mRNA vaccines can be developed and produced quickly, making them prime candidates for immediate outbreak responses. Furthermore, clinical trials have demonstrated rapid protection following mRNA vaccination. Thus, we sought to investigate how quickly mRNA vaccines elicit antibody responses compared to other vaccine modalities. We first compared the immune kinetics of mRNA and DNA vaccines expressing SARS-CoV-2 spike in mice. We observed rapid induction of antigen-specific binding and neutralizin ...[more]