Ontology highlight
ABSTRACT:
SUBMITTER: Ierano C
PROVIDER: S-EPMC3571999 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Ierano Caterina C Basseville Agnes A To Kenneth K W KK Zhan Zhirong Z Robey Robert W RW Wilkerson Julia J Bates Susan E SE Scala Stefania S
Cancer biology & therapy 20121128 2
The stromal cell-derived factor-1α SDF-1α (CXCL12)/CXCR4 axis has been linked to poor prognosis in some cancers. As histone deacetylase inhibitors (HDIs) exert antitumor effects by targeting proteins affecting cell migration, we sought to evaluate the effects of the HDIs apicidin, vorinostat, entinostat (MS-275) and romidepsin on the expression and function of CXCR4 in human cancer cell lines. After treatment with romidepsin, CXCR4 mRNA expression increased 12-fold in UOK121 renal cancer cells, ...[more]