Dataset Information

Maternal and pregnancy related predictors of cardiometabolic traits in newborns.

ABSTRACT:

Background

The influence of multiple maternal and pregnancy characteristics on offspring cardiometabolic traits at birth is not well understood and was evaluated in this study.

Methods and findings

The Family Atherosclerosis Monitoring In earLY life (FAMILY) Study prospectively evaluated 11 cardiometabolic traits in 901 babies born to 857 mothers. The influence of maternal age, health (pre-pregnancy weight, blood pressure, glycemic status, lipids), health behaviors (diet, activity, smoking) and pregnancy characteristics (gestational age at birth, gestational weight gain and placental-fetal ratio) were examined. Greater gestational age influenced multiple newborn cardiometabolic traits including cord blood lipids, glucose and insulin, body fat and blood pressure. In a subset of 442 singleton mother/infant pairs, principal component analysis grouped 11 newborn cardiometabolic traits into 5 components (anthropometry/insulin, 2 lipid components, blood pressure and glycemia), accounting for 74% of the variance of the 11 outcome variables. Determinants of these components, corrected for sex and gestational age, were examined. Baby anthropometry/insulin was independently predicted by higher maternal pre-pregnancy weight (standardized estimate 0.30) and gestational weight gain (0.30; both p<0.0001) and was inversely related to smoking during pregnancy (-0.144; p?=?0.01) and maternal polyunsaturated to saturated fat intake (-0.135;p?=?0.01). Component 2 (HDL-C/Apo Apolipoprotein1) was inversely associated with maternal age. Component 3 (blood pressure) was not clustered with any other newborn cardiometabolic trait and no associations with maternal pregnancy characteristics were identified. Component 4 (triglycerides) was positively associated with maternal hypertension and triglycerides, and inversely associated with maternal HDL and age. Component 5 (glycemia) was inversely associated with placental/fetal ratio (-0.141; p?=?0.005). LDL-C was a bridging variable between the lipid factors and glycemia.

Conclusions

Maternal health, health behaviours and placenta to fetal weight ratio are associated with newborn cardiometabolic traits over and above gestational age. Future investigations are needed to determine if these factors remain important determinants of cardiometabolic health throughout childhood.

SUBMITTER: Morrison KM

PROVIDER: S-EPMC3572188 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Maternal and pregnancy related predictors of cardiometabolic traits in newborns.

Morrison Katherine M KM Anand Sonia S SS Yusuf Salim S Atkinson Stephanie A SA Schulze Karleen M KM Rao-Melacini Purnima P McQueen Matthew J MJ McDonald Sarah S Persadie Richard R Hunter Barry B Bourgeois Jacqueline J Jansen Jan W JW Teo Koon K KK

PloS one 20130213 2

<h4>Background</h4>The influence of multiple maternal and pregnancy characteristics on offspring cardiometabolic traits at birth is not well understood and was evaluated in this study.<h4>Methods and findings</h4>The Family Atherosclerosis Monitoring In earLY life (FAMILY) Study prospectively evaluated 11 cardiometabolic traits in 901 babies born to 857 mothers. The influence of maternal age, health (pre-pregnancy weight, blood pressure, glycemic status, lipids), health behaviors (diet, activity ...[more]

PMID: 23418462

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Dataset Information

Maternal and pregnancy related predictors of cardiometabolic traits in newborns.

Background

Methods and findings

Conclusions

Publications

Maternal and pregnancy related predictors of cardiometabolic traits in newborns.

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