Ontology highlight
ABSTRACT:
SUBMITTER: Kelly CV
PROVIDER: S-EPMC3572836 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Kelly Christopher V CV Leroueil Pascale R PR Orr Bradford G BG Banaszak Holl Mark M MM Andricioaei Ioan I
The journal of physical chemistry. B 20080712 31
The molecular structures and enthalpy release of poly(amidoamine) (PAMAM) dendrimers binding to 1,2-dimyristoyl- sn-glycero-3-phosphocholine (DMPC) bilayers were explored through atomistic molecular dynamics. Three PAMAM dendrimer terminations were examined: protonated primary amine, neutral acetamide, and deprotonated carboxylic acid. Fluid and gel lipid phases were examined to extract the effects of lipid tail mobility on the binding of generation-3 dendrimers, which are directly relevant to t ...[more]