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Molecular definition of the identity and activation of natural killer cells.

ABSTRACT: Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cells are known to share expression of a few genes with cytotoxic CD8(+) T cells, our transcriptome-wide analysis demonstrates that the commonalities extend to hundreds of genes, many encoding molecules with unknown functions. Resting NK cells demonstrate a 'preprimed' state compared with naive T cells, which allows NK cells to respond more rapidly to viral infection. Collectively, our data provide a global context for known and previously unknown molecular aspects of NK cell identity and function by delineating the genome-wide repertoire of gene expression of NK cells in various states.

SUBMITTER: Bezman NA

PROVIDER: S-EPMC3572860 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Molecular definition of the identity and activation of natural killer cells.

Bezman Natalie A NA Kim Charles C CC Sun Joseph C JC Min-Oo Gundula G Hendricks Deborah W DW Kamimura Yosuke Y Best J Adam JA Goldrath Ananda W AW Lanier Lewis L LL

Nature immunology 20120819 10

Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cells are known to share expression of a few genes with cytotoxic CD8(+) T cells, our transcriptome-wide analysis demonstrates that the commonalities extend to hundreds of genes, many ...[more]

PMID: 22902830

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