Unknown

Dataset Information

0

ImmunoChip study implicates antigen presentation to T cells in narcolepsy.

ABSTRACT: Recent advances in the identification of susceptibility genes and environmental exposures provide broad support for a post-infectious autoimmune basis for narcolepsy/hypocretin (orexin) deficiency. We genotyped loci associated with other autoimmune and inflammatory diseases in 1,886 individuals with hypocretin-deficient narcolepsy and 10,421 controls, all of European ancestry, using a custom genotyping array (ImmunoChip). Three loci located outside the Human Leukocyte Antigen (HLA) region on chromosome 6 were significantly associated with disease risk. In addition to a strong signal in the T cell receptor alpha (TRA@), variants in two additional narcolepsy loci, Cathepsin H (CTSH) and Tumor necrosis factor (ligand) superfamily member 4 (TNFSF4, also called OX40L), attained genome-wide significance. These findings underline the importance of antigen presentation by HLA Class II to T cells in the pathophysiology of this autoimmune disease.

SUBMITTER: Faraco J 

PROVIDER: S-EPMC3573113 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

ImmunoChip study implicates antigen presentation to T cells in narcolepsy.

Faraco Juliette J   Lin Ling L   Kornum Birgitte Rahbek BR   Kenny Eimear E EE   Trynka Gosia G   Einen Mali M   Rico Tom J TJ   Lichtner Peter P   Dauvilliers Yves Y   Arnulf Isabelle I   Lecendreux Michel M   Javidi Sirous S   Geisler Peter P   Mayer Geert G   Pizza Fabio F   Poli Francesca F   Plazzi Giuseppe G   Overeem Sebastiaan S   Lammers Gert Jan GJ   Kemlink David D   Sonka Karel K   Nevsimalova Sona S   Rouleau Guy G   Desautels Alex A   Montplaisir Jacques J   Frauscher Birgit B   Ehrmann Laura L   Högl Birgit B   Jennum Poul P   Bourgin Patrice P   Peraita-Adrados Rosa R   Iranzo Alex A   Bassetti Claudio C   Chen Wei-Min WM   Concannon Patrick P   Thompson Susan D SD   Damotte Vincent V   Fontaine Bertrand B   Breban Maxime M   Gieger Christian C   Klopp Norman N   Deloukas Panos P   Wijmenga Cisca C   Hallmayer Joachim J   Onengut-Gumuscu Suna S   Rich Stephen S SS   Winkelmann Juliane J   Mignot Emmanuel E  

PLoS genetics 20130214 2

Recent advances in the identification of susceptibility genes and environmental exposures provide broad support for a post-infectious autoimmune basis for narcolepsy/hypocretin (orexin) deficiency. We genotyped loci associated with other autoimmune and inflammatory diseases in 1,886 individuals with hypocretin-deficient narcolepsy and 10,421 controls, all of European ancestry, using a custom genotyping array (ImmunoChip). Three loci located outside the Human Leukocyte Antigen (HLA) region on chr  ...[more]

Similar Datasets

Unknown Upregulation of type 1 conventional dendritic cells implicates antigen cross-presentation in multisystem inflammatory syndrome.
| S-EPMC8530782 | biostudies-literature
Unknown Apoptotic cells deliver processed antigen to dendritic cells for cross-presentation.
| S-EPMC1084338 | biostudies-literature
Unknown Serine Proteases Enhance Immunogenic Antigen Presentation on Lung Cancer Cells.
| S-EPMC5673248 | biostudies-literature
Unknown Ap4A Regulates Directional Mobility and Antigen Presentation in Dendritic Cells.
| S-EPMC6595237 | biostudies-literature
Unknown Indirect involvement of allergen-captured mast cells in antigen presentation.
| S-EPMC2214744 | biostudies-literature
Unknown Autophagy links antimicrobial activity with antigen presentation in Langerhans cells.
| S-EPMC6538337 | biostudies-literature
Unknown Alternative splicing of MR1 regulates antigen presentation to MAIT cells.
| S-EPMC7508857 | biostudies-literature
Unknown Antigen Presentation After Stroke.
| S-EPMC5081119 | biostudies-literature
Unknown Autonomous phagosomal degradation and antigen presentation in dendritic cells.
| S-EPMC3437883 | biostudies-other
Unknown Mechanisms of antigen presentation to T cells in murine graft-versus-host disease: cross-presentation and the appearance of cross-presentation.
| S-EPMC3236124 | biostudies-literature