Ontology highlight
ABSTRACT:
SUBMITTER: Yin X
PROVIDER: S-EPMC3573230 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Yin Xiaoke X Dwyer Joseph J Langley Sarah R SR Mayr Ursula U Xing Qiuru Q Drozdov Ignat I Nabeebaccus Adam A Shah Ajay M AM Madhu Basetti B Griffiths John J Edwards Lindsay M LM Mayr Manuel M
Journal of molecular and cellular cardiology 20121229
Perhexiline is a potent anti-anginal drug used for treatment of refractory angina and other forms of heart disease. It provides an oxygen sparing effect in the myocardium by creating a switch from fatty acid to glucose metabolism through partial inhibition of carnitine palmitoyltransferase 1 and 2. However, the precise molecular mechanisms underlying the cardioprotective effects elicited by perhexiline are not fully understood. The present study employed a combined proteomics, metabolomics and c ...[more]