Ontology highlight
ABSTRACT:
SUBMITTER: Wie SH
PROVIDER: S-EPMC3573720 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20121231 2
HIV is able to outpace the innate immune response, including that mediated by interferon (IFN), to establish a productive infection. Primary macrophages, however, may be protected from HIV infection by treatment with type I IFN before virus exposure. The ability of HIV to modulate the type I IFN-mediated innate immune response when it encounters a cell that has already been exposed to IFN remains poorly defined. The optimal pretreatment time (12 h) and the most potent HIV-inhibitors (e.g., IFN-α ...[more]